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Introduction
Ephedra, also
called ma huang, epitonin and sida cordifolia, contains stimulants
known chemically as ephedrine. The source of ephedra is a family
of shrubs. It is found in a Chinese herb called ma huang, and
it is totally unregulated in most places. Also known Mormon tea
or Brigham tea, this Chinese herb has been used for over 2000
years.
Ephedrine
was used during the 1970's and 1980's in a variety of over-the-counter
(OTC) medications. Uses included the treatment of asthma, nasal
congestion and weight loss. Although somewhat effective for these
conditions ephedrine had side effects that could be dangerous
for some patients.
Far safer
and more effective medications, called selective beta-agonists,
were developed for the treatment of asthma and largely replaced
ephedrine for treatment of asthma by the early 1980's. Likewise,
the development of non-sedating antihistamines and topical nasal
steroid sprays in the mid to late 1980's greatly decreased the
use of OTC products for severe allergic rhinitis. Serious problems
were reported with the misuse of ephedrine as a weight loss pill
during this period. (Amphetamines, ephedrine's more potent chemical
cousin, had run into many problems as an energy boosting and weight
loss aid and been banned years earlier.)
The final
straw in OTC ephedrine products coincided with the explosion of
methamphetamine production and usage in the mid to late 1980's.
When it was determined that the bulk of ephedrine manufactured
was going to the production of illegal methamphetamine ephedrine
sale was banned. It should be noted that an alternative would
have been to make ephedrine a prescription or controlled substance
whose sale and production could be closely monitored. The most
likely reason this did not happen was ephedrine would not have
had much of a market as a prescription medication. As previously
discussed, more effective and safer medications were already available
for almost all conditions that ephedrine treated.
Ephedra resurfaced
in a variety of forms in the 1990's. Marketed as a dietary supplement,
not a drug, Ma Huang reintroduced ephedrine to the general public.
Ephedrine was not disclosed as the active ingredient in most Ma
Huang preparations. Products containing ephedrine were marketed
for weight loss (an herbal alternative to Fen-Phen), as legal
alternatives to street drugs (herbal ecstasy), as antidepressants,
and as athletic/ body building enhancers.
Rick Demont
was a 16 year old swimmer who was stripped of his gold medal at
the 1972 Olympics after testing positive for unacceptable levels
of ephedrine. Rick did use an ephedrine containing asthma medication
at the time.
Common
Uses
- Asthma,
allergies, weight loss, euphoric high, improved endurance
- Caffeine
and herbal products containing caffeine, such as cola nut, are
sometimes added to ephedra supplements
At best you
can expect temporary suppression of appetite, a racing heart,
and clear nasal passages and lungs.
Dosage
- We do not
support use of ephedrine unless under the supervision of a physician.
- Safe dose
unknown. FDA (Food and Drug Administration) has proposed maximal
dose of 24 milligrams per 24 hours. However, serious adverse
effects have occurred at lower daily doses.
Side Effects
- (common)
Insomnia, nervousness, tremor, headaches, high blood pressure,
palpitations
- (much
less common)
Seizures, stroke, heart attack, heart arrhythmias, death
- More likely
to occur with use greater than one week.
- Persons
on certain types of antidepressants (MAO inhibitors) may experience
severe elevation of blood pressure, increasing their risk of
stroke, if using ephedra containing compounds.
- Enhances
the effect of caffeine, pseudoephedrine and phenopropanolamine.
To date,
ephedra has been directly associated with eighteen deaths and
more than 800 nonfatal "adverse events."
Conditions
where Ephedra should not be taken
- Diabetes
- High blood
pressure
- Psychiatric
conditions
- Prostate
enlargement
- Glaucoma
- Epilepsy
(seizure disorders)
- Heart disease
- Pregnant
or Nursing (never use)
Bottom
line
The risk of
ephedrine-containing compounds currently, as well as in the past,
outweighs benefits. It is not that ephedrine does not work- it
does. The problem is ephedrine does not work well enough to justify
the potentially serious risks such as heart attack, stroke, or
drug abuse.
Don't fall
for the "all-natural" sales pitch. Ephedra's active ingredient
is still a drug, and shouldn't be used as a weight loss aid or
energy booster. There are safer and more effective medications
for virtually every condition ephedrine claims to treat with the
possible exception of stimulant activity. We realize that many
prescription medications are expensive. "Herbal ephedra"
sold by various companies can cost up to $150 for a single month
supply rivaling the most expensive prescriptions. We believe that
your life and health are precious!
Top
Resources
"Herbal
Remedies: Adverse Effects and Drug Interactions" Melanie
Johns Cupp, PHARM.D. in American Family Physician, March
1999 vol 59, no. 5: 1239-1244.
Viewable online @ http://www.aafp.org/afp/990301ap/1239.html
Phys:
The Dirt On Diet Pills: Ephedra/Ma Huang
Viewable online @ http://www.phys.com/b_nutrition/02solutions/08diet/ephedra.htm
FDA
Talk Paper-"FDA WARNS AGAINST DRUG PROMOTION OF "HERBAL
FEN-PHEN"
Viewable
online @ http://www.fda.gov/bbs/topics/ANSWERS/ANS00832.html
Doctors
Corner INternet Group, Inc. 1997-2004
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